Puromycin dihydrochloride

Supplier: MP Biomedicals

Synonyms: (S)-2-Amino-N-((2S,3S,4R,5R)-5-(6-(Dimethylamino)-9H-purin-9-yl)-4-hydroxy-2-(hydroxymethyl)tetrahydrofuran-3-yl)-3-(4-methoxyphenyl)propanamide dihydrochloride

0210055210 0210055225 0210055280 0210055283 0210055290 0210055291
ICNA0210055210EA 115 SGD
ICNA0210055210 ICNA0210055225 ICNA0210055280 ICNA0210055283 ICNA0210055290 ICNA0210055291
Puromycin dihydrochloride
Puromycin dihydrochloride

Puromycin is nucleoside antibiotic & protein synthesis inhibitor that causes premature chain termination by acting as an analogue of the 3′-terminal end of aminoacyl-tRNA. Prevents growth of bacteria, protozoa, algae, and mammalian cells.


Puromycin is an antibiotic of unique structure and biological activity. It is produced by fermentation using Streptomyces albo-niger. There are four aspects of puromycin's biological activity that are 1) anti tumour effect; 2) nephrotoxic action; 3) inhibition of purine and/or protein synthesis and 4) antitrypanosome activity.


Soluble in water (50 mg/ml - clear, colorless solution).

Formula: C₂₂H₂₉N₇O₅·2HCl
MW: 544,44 g/mol
MDL Number: MFCD00012691
CAS Number: 58-58-2

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Specification Test Results

Synonyms 6-dimethylamino-9-(3'-deoxy-3'-(p-methoxy-L-phenylalanyamino)- B-D-ribofuranosyl)-purine
Form Off-white Powder
Storage Store at -0 °C
Extinction Coefficient 20,3 (275 nm; 0,1 N NaOH); 19,5 (268 nm, 0,1 NHCl) (Lit.)
pka 6,8; 7,2 (Lit.)
Source Streptomyces albo-niger

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