Trimethoprim, white powder

Supplier: MP Biomedicals
Warning

Synonyms: 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine, 2,4-Diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine

0219552701 0219552705 0219552725 0219552780
ICNA0219552701EA 88.7 SGD
ICNA0219552701 ICNA0219552705 ICNA0219552725 ICNA0219552780
Trimethoprim, white powder
Trimethoprim

Trimethoprim is an antibacterial agent; a specific inhibitor of formylation; a dihydrofolate reductase inhibitor.
Trimethoprim is primarily used as an antibacterial agent. It has dihydrofolate reductase inhibitor activity with selectivity for the prokaryote enzyme. It is used to treat urinary tract infections, mild acute prostatitis, recurrent cystitis, asymptomatic bacteriuria during pregnancy and respiratory tract infections.
The combination of trimethoprim and sulfamethoxazole interferes with the cellular metabolism of folic acid in the bacterial cell by blocking the biosynthesis of nucleotides. Trimethoprim binds to dihydrofolate reductase and inhibits the reduction of dihydrofolic acid (DHF) to tetrahydrofolic acid (THF). THF is an essential precursor in the thymidine synthesis pathway and interference with this pathway inhibits bacterial DNA synthesis.


  • Presentation: White Powder
  • Soluble in a hot 1:1 solution of ethanol:chloroform (50 mg/mL - clear, colorless to faint yellow solution); soluble in chloroform (15 mg/mL - clear, colorless solution), propylene glycol (25 mg/mL), methanol (12 mg/mL); very slightly soluble in water (0.4 mg/mL).
  • +4 °C


Trimethoprim is an antibacterial agent; a specific inhibitor of formylation; a dihydrofolate reductase inhibitor.


Trimethoprim is primarily used as an antibacterial agent. It has dihydrofolate reductase inhibitor activity with selectivity for the prokaryote enzyme. It is used to treat urinary tract infections, mild acute prostatitis, recurrent cystitis, asymptomatic bacteriuria during pregnancy and respiratory tract infections.

Formula: C₁₄H₁₈N₄O₃
MW: 290,32 g/mol
Melting Pt: 196…206 °C
Storage Temperature: Refrigerator
MDL Number: MFCD00036761
CAS Number: 738-70-5

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