Hydroxypropyl-β-cyclodextrin, white powder

Supplier: MP Biomedicals

Synonyms: HBC, 2-Hydroxypropylether-b-cyclodextrin

0215354001 0215354005
ICNA0215354001EA 77.7 SGD
ICNA0215354001 ICNA0215354005
Hydroxypropyl-β-cyclodextrin, white powder
Hydroxypropyl-β-cyclodextrin

2-Hydroxypropyl-beta-cyclodextrin are non-toxic solubilisers. The solubility of drugs increases linearly with the concentration of 2-Hydroxypropyl-b-cyclodextrin in aqueous buffer. The formation of drug/cyclodextrin complexes is a rapidly reversible reaction and complexes exist both in solution and crystalline states.


Solutions of many such complexes may be lyophilised to produce freely soluble powders which may be compressed into tablets. Bio-effects are only slightly affected by cyclodextrin complexation. Cells in serum supplemented medium can be grown in up to 1 to 2%. In serum-free medium, concentrations of 0,5 to 1% are acceptable. Hydroxypropyl-b-cyclodextrin has been found to be non-toxic in mice and rabbits. 2-hydroxypropyl-g-cyclodextrin with its 8 glucose units, has a slightly larger cavity and can accomodate larger substrates than the beta form. The use of cyclodextrins in receptor binding assays in not recommended.


Soluble in water (50 g/100 ml). Solutions may be obtained by stirring 30 minutes at room temperature. Alternatively, sonication with cooling may be employed. Solutions may be stored for several weeks at room temperature. Good solubility in methanol, ehtanol, pyridine, dimethyl sulphoxide, dimethyl formamide.

Formula: C₅₄H₁₀₂O₃₉
MW: 1375,371 g/mol
MDL Number: MFCD16621721
CAS Number: 94035-02-6

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