Ristocetin A ≥90%, off-white powder
Supplier: MP Biomedicals
Ristocetin A is an antibiotic that belongs to the class III glycopeptides. The compound has activity against gram-positive and gram-negative bacteria, and can be used in chromatography. Ristocetin A is structurally related to the glycopeptide antibiotics Teicoplanin and vancomycin.
Ristocetin A has platelet aggregating activity and has been used in platelet aggregation studies. Studies have demonstrated that Ristocentin A dimerizes and creates two binding sites for cell wall peptides.
Ristocetin activates platelets. Ristocetin-induced platelet agglutination (RIPA) is decreased in patients undergoing chronic hemodialysis. Together with increased plasma glycocalicin levels (a product of enzymatic cleavage of GPIb), RIPA may contribute to diminished platelet adhesion to vascular subendothelium and increased bleeding associated with uremia. Addition of ristocetin and vWf caused specific agglutination of rGPIbα-liposomes suporting the potential use of rGPIbα-liposomes to enhance platelet function in vivo and support hemostasis in thrombocytopenic individuals.
Soluble in 1 N HCl (50 mg/ml - clear and colorless to pale yellow); soluble in water (clear 5 mg+ 0,25 ml, amber solution).
Formula:
C₉₅H₁₁₀N₈O₄₄ MW: 2067,937 g/mol Storage Temperature: Refrigerator |
CAS Number:
1404-55-3 |
Specification Test Results
Identity Test | Passes |
Potency (µg/mg) | Report Result |
Purity | ≥90% Ristocetin A |
Ristocetin B Sulfate | Report Result |
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