Tris(hydroxymethyl)aminomethane (TRIS, Trometamol) ≥99.9%, white crystalline powder, Ultrapure

Supplier: MP Biomedicals
Warning

Synonyms: 2-Amino-2-(hydroxymethyl)propane-1,3-diol(tris), Tromethamine, Tris(hydroxymethyl)methylamine, 2-Amino-2-(hydroxymethyl)propane-1,3-diol, 2-Amino-2-(hydroxymethyl)-1,3-propanediol, Trizma(R) base, TRIS base, THAM

02103133.1 02103133.5 02103133.2 0210313301 0210313305 0210313310
ICNA02103133.1EA 87.4 SGD
ICNA02103133.1 ICNA02103133.5 ICNA02103133.2 ICNA0210313301 ICNA0210313305 ICNA0210313310
Tris(hydroxymethyl)aminomethane (TRIS, Trometamol) ≥99.9%, white crystalline powder, Ultrapure
Tris(hydroxymethyl)aminomethane (TRIS, Trometamol)

Tris have been useful as buffers in a wide variety of biological systems. It has been used as a starting material for polymers, oxazolones (with carboxylic acids) and oxazolidines (with aldehydes). It does not precipitate calcium salts and is of value in maintaining solubility of manganese salts. It can be used for the direct standardization of a strong acid solution; the equivalence point can be determined either potentiometrically or by use of a suitable indicator such as 3-(4-Dimethylamino-1-naphthylazo)-4-methoxybenzenesulfonic acid. It is RNAse and DNAse-free. Tris is relatively non-hygroscopic ; but, if needed, it can be dried at 100 °C for up to 4 hours to remove any water.
Tris is used in pH control in vitro and in vivo for body fluids and in buffering systems for electrophoresis applications.Tris is used in assays used to characterize the activity and kinetics of the enzymes that catalyze SUMOylation of Small ubiquitin-like proteins (SUMO) and SUMO-dependent protein-protein interactions.


  • Ultra Pure Grade
  • Presentation: White Crystalline Powder
  • Vapor Pressure: Low at ambient temperatures
  • pKa: 8.1 at 25 °C (Lit.)
  • Storage temperature: Store at Room Temperature, desiccate.


pH: 10-11.5 (5% aq soln)

Formula: NH₂C(CH₂OH)₃
MW: 121,14 g/mol
Boiling Pt: 219…220 °C (10 mmHg)) (lit.)
Melting Pt: 165…175 °C
Storage Temperature: Ambient
MDL Number: MFCD00004679
CAS Number: 77-86-1
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Specification Test Results

Identity Test Passes
Purity ≥99.9%
FTIR Conforms to Standard
Melting Point 165-175°C
pH (5% aq soln) 10-11.5
OD260 nm (5% aq soln) ≤0.1
Loss on Drying ≤1%
Solubility (40% aq soln) Clear, Colorless Solution

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