1-(Trimethylsilyl)imidazole silylation reagent, for GC derivatisation
Supplier: MACHEREY-NAGEL
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Danger
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Synonyms:
TSIM, N-(Trimethylsilyl)imidazole, N-(Trimethylsilyl)-1H-imidazole, TMSI, 1-(Trimethylsilyl)-1H-imidazole
TSIM is the strongest hydroxyl silylator; reagent of choice for carbohydrates and most steroids (even highly hindered steroids).
- Silylation can be applied on many compounds
- Silylation reagents are easily prepared
- TSIM selectively derivatizes compounds with different functional groups
The reagent is unique in that it reacts quickly and smooth with hydroxyl (even tert. OH) and carboxyl groups, but not with amines. This characteristic makes TSIM particularly useful in multi-derivatization schemes for compounds with different functional groups, which are to be derivatized differently (e.g., -O-TMS / -N-HFB derivatives of catecholamines). Recommended applications are the derivatizatzion of alcohols, phenols, organic acids, steroids, hormones, glycols, nucleotides and narcotics.
Formula:
C₆H₁₂N₂Si MW: 140,26 g/mol Boiling Pt: 94–96 °C (760 mm Hg) Density: 0,961 g/cm³ (d20°/4°) |
MDL Number:
MFCD00005280 CAS Number: 18156-74-6 |
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