Dexamethasone, white powder
Supplier: MP Biomedicals
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Danger
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Synonyms:
Dexamethasonum, 9-Fluor-16α-methyl-11β,17α,21-trihydroxy-1,4-pregnadien-3,20-dion
Dexamethasone is an anti-inflammatory glucocorticoid that induces the production of phospholipase A2 inhibitory protein (lipocortin).
It also inhibits induction of nitric oxide synthase (IC50=5 nM). Dexamethasone has been shown to cause reduction in cyclin A and Cdk2 activity, inhibition of G1/S transition in osteoblasts and inhibition of phosphorylation of Rb protein. Dexamethasone has been observed to induce apoptosis in human thymocytes and eosinophils but to inhibit apoptosis in neutrophils.
Dexamethasone is a glucocorticoid anti-inflammatory agent. It regulates T cell survival, growth, and differentiation. It also inhibits the induction of nitric oxide synthase.
Slightly soluble in water (10 mg/100 ml), ethanol (1 mg/ml), chloroform; sparingly soluble in acetone, alcohol, dioxane, and methanol; very slightly soluble in ether
Formula:
C₂₂H₂₉FO₅ MW: 392,47 g/mol Melting Pt: 262…264 °C (lit.) |
MDL Number:
MFCD00064136 CAS Number: 50-02-2 EINECS: 200-003-9 |
Specification Test Results
Identity Test | Passes |
FTIR | Conforms to Standard C |
Loss on Drying | ≤5,0% |
Optical Rotation | +72 ° to +80 ° (c=1, dioxane) |
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