D-Cycloserine, off-white powder

Supplier: MP Biomedicals
Warning

Synonyms: D-(+)-Cycloserine, Cycloserine, D(+)-Cycloserine, (R)-4-Aminoisoxazolidin-3-one, D-4-Aminoisoxazolidin-3-one, (R)-(+)-Cycloserine

0210053510 0210053525 0210053580 0210053583
ICNA0210053510EA 83.9 SGD
ICNA0210053510 ICNA0210053525 ICNA0210053580 ICNA0210053583
D-Cycloserine, off-white powder
D-Cycloserine

Synthetic Bactericidal Antibiotic. A structural analog of D-Alanine. A partial agonist at the glycine modulatory site of NMDA receptors; enhances learning and memory in several models of cognitive deficit; anticonvulsant (at high doses). Antibiotic against gram-negative bacteria that acts by inhibiting the synthesis of the cell wall (D-Ala peptide bond formation).


Mode of Action: Inhibits cell wall biosynthesis (D-Ala peptide bond formation). Also prevents conversion of D-Ala to L-Ala. Bacteriostatic. Mode of Resistance: D-Ala transport interference.
Partial agonist at the glycine modulatory site of NMDA glutamatergic receptors; antibiotic against Gram-negative bacteria.


Soluble in water (up to 100 mg/ml - clear, colorless to faint yellow solution), 96% ethanol (1 in 50 parts ethanol); slightly soluble in methanol or propylene glycol; practically insoluble in chloroform and ether.

Formula: C₃H₆N₂O₂
MW: 102,09 g/mol
Storage Temperature: Freezer
MDL Number: MFCD00005353
CAS Number: 68-41-7
EINECS: 200-688-4

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Specification Test Results

Identity Test Passes
Potency ≥900 µg/mg
FTIR Conforms to Standard
pH (2% aq soln) 5,5 - 6,5
Solubility (5% aq soln) Clear, Colorless to Slightly Pink to Yellow Solution
Typical Working Concentration 100-200 µg/ml. Prepare just before use using 0,1 M sodium phosphate buffer, pH 8,0,

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