E-64 ((2S,3S)-(+)-trans-Epoxy succinyl-L-leucylamido-4-guanidino butane)

Supplier: MP Biomedicals

0215284605 0215284601 0215284610
ICNA0215284605EA 447 SGD
ICNA0215284605 ICNA0215284601 ICNA0215284610
E-64 ((2S,3S)-(+)-trans-Epoxy succinyl-L-leucylamido-4-guanidino butane)
Proteins and Peptides

E-64 is an inhibitor for thiol protease, papain, actinidin, ananain, bromelain, calpain and cathepsin B. An irreversible cysteine protease inhibitor that has no action on cysteine residues in other plants. It does not react with low molecular weight thiols such as 2-mercaptoethanol.


  • Specific active site titrant
  • Soluble in 50% acetic acid, water, or DMSO


It is an effective ligand for affinity purification of cysteine proteases. When coupled to a thiolated affinity matrix, binding is no longer irreversible, but specificity is retained.

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