E-64 ((2S,3S)-(+)-trans-Epoxy succinyl-L-leucylamido-4-guanidino butane), MP Biomedicals

Supplier: MP Biomedicals

0215284605 0215284601 0215284610
ICNA0215284605EA 449 SGD
ICNA0215284605 ICNA0215284601 ICNA0215284610
E-64 ((2S,3S)-(+)-trans-Epoxy succinyl-L-leucylamido-4-guanidino butane), MP Biomedicals
Proteins and Peptides

E-64 is an inhibitor for thiol protease, papain, actinidin, ananain, bromelain, calpain and cathepsin B. An irreversible cysteine protease inhibitor that has no action on cysteine residues in other plants. It does not react with low molecular weight thiols such as 2-mercaptoethanol.


  • Specific active site titrant
  • Soluble in 50% acetic acid, water, or DMSO


It is an effective ligand for affinity purification of cysteine proteases. When coupled to a thiolated affinity matrix, binding is no longer irreversible, but specificity is retained.

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SPECIFICATIONS

Protein/peptide name E-64 ((2S,3S)-(+)-trans-Epoxy succinyl-L-leucylamido-4-guanidino butane)
Environmentally Preferable
Species
Source
CAS No. 66701-25-5
MDL No. MFCD00080261
Molecular weight 357,4 kDa
Molecular formula C₁₅H₂₇N₅O₅
Storage conditions −20 °C

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