You Searched For: Methotrexate

Supplier: Thermo Scientific

Description: Methotrexate

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Supplier: Thermo Scientific

Description: Used as an intermediate in the production of Methotrexate.

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Supplier: MP Biomedicals

Description: Folic Acid antagonist; structurally similar to folic acid. Methotrexate is a mixture of 4-amino-10-methylfolic acid and closely related compounds.

Catalog Number: (EDQMM1000000)

Supplier: EDQM

Supplier Article Number:: M1000000

Description: Methotrexate

UOM: 1 * 100 mg

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Supplier: MP Biomedicals

Description: Methotrexate is a cell cycle arresting agent with varying effects. Methotrexate has been reported to arrest the cell cycle in late G1/S thus leading to the inhibition of the synthesis of DNA, RNA, thymidylates, and proteins. The main mechanism of action is reported to involve the inhibition of enzymes involved in purine metabolism which leads to the accumulation of adenosine or the suppression of intercellular adhesion molecule expression by T cells. Additionally, this compound has been observed to inhibit DHFR.
Methotrexate is used for chemotherapy either alone or in combination with other agents. It is effective for the treatment of a number of cancers including: breast, head and neck, leukemia, lymphoma, lung, osteosarcoma, bladder, and trophoblastic neoplasms. It is also used in treatment of autoimmune diseases, ectopic pregnancy, and for the induction of medical abortions. It is used to inhibit dihydrofolate reductase in DHFR-based protein expression systems. Also effective in treatment of pyrimethamine-resistant Plasmodium vivax malaria parasites.
Potent inhibitor of dihydrofolate reductase and agent for antitumor studies. Use to inhibit dihydrofolate reductase in DHFR-based protein expression systems. Also shows immunosuppressive effects in, e.g., rheumatoid arthritis.
Methotrexate is an allosteric inhibititor of dihydrofolate reductase (DHFR), the enzyme that catalyzes the conversion of dihydrofolate to tetrahydrofolate. Since tetrahydrolfolate is required for purine and pyrimidine synthesis, Methotrexate treatment results in the inhibition of DNA and RNA synthesis.

Catalog Number: (EDQMM1000008)

Supplier: EDQM

Supplier Article Number:: M1000008

Description: Filled under inert atmosphere protected from humidity.

UOM: 1 * 10 mg

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Supplier: MP Biomedicals

Description: Poly-lysine is a polycation which binds to DNA, red cell membrane and any negatively charged protein. When adsorbed to the culture surface, poly-lysine increases the number of positively charged sites available for cell binding. A compromise between the easier to use lower molecular weight products and the extremely viscous higher molecular weights would be the products in the range of 70,000-150,000.
It is typically used as a coating substrate for culture dishes, slides, etc. It enhances electrostatic interaction between negatively charged ions of the cell membrane and the culture surface. Both the D- and L- form of the poly-lysine can be used as a coating substrate since poly-lysine is a nonspecific attachment factor for cells; however, certain cells can digest poly-lysine. In this case, poly-D-lysine should be used as the attachment factor so that the cells are not disrupted by excessive uptake of L-lysine.
Other uses for poly-lysine have been reported as well:
• Conjugation to methotrexate for increased drug transport.
• Microencapsulation of islets.
• Use in simple reproducible procedure for chromosomal preparations from a variety of tissues.
• Immobilation of living cells in biocompatible semipermeable microcapsules.
• In the preparation of polycationic beads.
• Conjugation to albumin and horseradish peroxidase to enhance cellular uptake.
Poly-D-lysine hydrobromide is a synthetic amino acid that enhances cell adhesion to solid substrates. It has additionally been shown to eliminate prion proteins from infected cells.

Catalog Number: (EDQMY0000663)

Supplier: EDQM

Supplier Article Number:: Y0000663

Description: METHOTREXATE IMPURITY C 1 * 10 mg

UOM: 1 * 10 mg

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Catalog Number: (HIMETC404-250MG)

Supplier: HIMEDIA

Supplier Article Number:: TC404-250MG

Description: Methotrexate Disodium salt 1 * 250 mg

UOM: 1 * 250 mg

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Catalog Number: (EDQMY0000664)

Supplier: EDQM

Supplier Article Number:: Y0000664

Description: METHOTREXATE IMPURITY E 1 * 10 mg

UOM: 1 * 10 mg

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Supplier: MP Biomedicals

Description: Folinic acid calcium salt, pentahydrate offsets the effects of folic acid antagonists that act by binding dihydrofolate reductase and blocking the conversion of folic acid to tetrahydrofolate.

Supplier: MP Biomedicals

Description: Poly-L-lysine is a positively charged amino acid polymer. Poly-lysine binds to DNA, red cell membrane and any negatively charged protein. It is typically used as a coating substrate for culture dishes, slides, etc. It enhances electrostatic interaction between negatively charged ions of the cell membrane and the culture surface. When adsorbed to the culture surface, poly-lysine increases the number of positively charged sites available for cell binding.

Supplier: MP Biomedicals

Description: Poly-L-Lysine is typically used as a coating substrate for culture dishes, slides, etc.

Supplier: MP Biomedicals

Description: There is approximately one HBr or HCl per lysine unit. The HBr/HCl allows it to be a crystalline solid and soluble in water. To remove the HBr/HCl, solubilise the product in a neutral buffer and dialyse away the salts.

Catalog Number: (ICNA0215269080)

Supplier: MP Biomedicals

Supplier Article Number:: 0215269080

Description: Poly-L-lysine is a nonspecific attachment factor for cells useful in promoting cell adhesion to solid substrates. It enhances electrostatic interaction between negatively charged ions of the cell membrane and the culture surface. When adsorbed to the culture surface, poly-L-lysine increases the number of positively charged sites available for cell binding. Polymers of both D- and L-lysine are used to coat solid surfaces.

UOM: 1 * 100 mg

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