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Detergent-based viral inactivation: a case study demonstrating enhanced monoclonal antibody purification

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Virus inactivation is a critical operation in therapeutic protein manufacturing. Detergent-based processes are effective at viral clearance prior to the downstream step, increasing the safety of the overall process, yet the most commonly used detergent presents environmental concerns.

A novel biodegradable detergent overcomes the ecotoxicity and regulatory issues, and extensive study data proves its capability of providing >6.5 log of viral inactivation and high virus-killing kinetics independent of operational temperatures (4 ⁰C to RT), in addition to other advantages.

This presentation was given at BioProduction, part of CPhI, October 23, 2023.

Presented by:

Dr. Nandu Deorkar

Dr. Nandu Deorkar
Senior Vice President, Research & Development – Biopharma Production, Avantor

Nandu Deorkar is Senior Vice President, Biopharma Production Research & Development for Avantor. He is responsible for innovation strategy and planning, and execution of new products and technology development. During his more than 25-year career in research & development, Dr. Deorkar has been leading teams working on various aspects of upstream and downstream bioprocessing, single use systems, chemical/polymer R&D, drug development, formulation, drug delivery technologies, process development, and technology transfer. He has published more than 30 articles and holds more than 20 patents. Dr. Deorkar received Ph.D. from Indian Institute of Technology, Mumbai, India and MBA in Marketing from Fairleigh Dickinson University, Madison, NJ, USA.